Antigen-based vs. systemic immunomodulation in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
Alternative Approach to Immunomodulation for Type 1 Diabetes: Antigen-Specific Immunotherapy In Utero.
Type 1 diabetes (T1D) results from the T-cell–mediated destruction of insulin-secreting pancreatic b-cells (1). While we can treat this condition with insulin replacement, long-term outcomes for patients is suboptimal (2), and a “cure” for T1D is a very worthy goal. At a time when significant progress is being made with biological therapies, surely a cure has to be possible. Many approaches to ...
متن کاملAntigen-based prediction and prevention of type 1 diabetes.
2. INTRODUCTION Type 1 (insulin dependent) diabetes develops as the result of a cumulative autoimmune-mediated destruction of the pancreatic beta cells mainly in genetically predisposed individuals. The disease becomes clinically manifest when 50-90% of the beta cells are destroyed (1) following a long prodromal period (months to years) during which autoimmune phenomena are often present, inclu...
متن کاملAntigen-Based Therapy for the Treatment of Type 1 Diabetes
A ntigen-based therapies (ABTs) seek to prevent or inhibit autoimmune diseases by inducing regulatory T-cell responses (active tolerance) or anergizing/deleting pathogenic T-cells (passive tolerance). The theoretical appeal of this therapeutic approach is that it may promote tolerance with little debilitation of the immune system. The clinical application of ABTs for autoimmune disease is still...
متن کاملAntigen targets of type 1 diabetes autoimmunity.
Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the immune system. The list of target antigens in this disease is ever increasing and it is conceivable that additional islet autoantigens, possibly including pivotal β-cell targets, remain to be discovered. Many knowledge gaps remain with respect to the disorder's pathogenesis, including the cause of loss of tole...
متن کاملCharacterization and Immunomodulation of Regulatory T Cells in Type 1 Diabetes
Kevin Scott Goudy: Characterization and Immunomodulation of Regulatory T cells in Type 1 Diabetes " Under the direction of Drs. Type 1 diabetes mellitus (T1D) is a chronic autoimmune disorder characterized by the complete destruction of the insulin-producing pancreatic β cells. The result of β cell loss leads to lifelong insulin injections in order to maintain blood glucose levels, and is assoc...
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ژورنال
عنوان ژورنال: Islets
سال: 2013
ISSN: 1938-2014,1938-2022
DOI: 10.4161/isl.24785